Sarcoidosis is a systemic disease which can affect many organs and systems, characterized by the formation of granulomas in the affected tissues (this is one of the diagnostic signs of the disease, which is detected by microscopic examination; limited foci of inflammation look as a dense nodule of various sizes).

In infiltrative sarcoidosis of the hypothalamic-pituitary area, patients may experience hypopituitarism of varying severity with the presence (or absence) of diabetes insipidus.

Sarcoidosis can progress and cause damage to the pituitary gland and form an empty sella syndrome.

Systemic glucocorticoids are used to treat sarcoidosis.