Gonadotropin-Secreting PA

Gonadotropinoma is a benign tumor (adenoma) of the pituitary gland, which develops from hormone-producing cells of the anterior pituitary gland – gonadotrophs, manifested by increased secretion of follicle-stimulating (FSH) and luteinizing (LH) hormones. These hormones regulate the biosynthesis of sex steroid hormones.
Hyperproduction of gonadotropic hormones by a tumor, even at a considerable size, may not produce any clinical manifestations, unless there is no compression of the parasellar structures. Sometimes, as a result of squeezing of healthy pituitary cells by adenoma, the hypopituitarism signs (including pituitary hypogonadism) may occur.

Treatment of gonadotropinoma

The therapeutic management in patients with gonadotropinomas in each case is selected individually and depends on the neurological, visual and other symptoms. As the treatment of gonadotropin, surgical, drug, radiation therapy, or combinations thereof can be used.