Thyrotropin-Secreting PA

Thyrotropinoma is a benign tumor (adenoma) of the pituitary gland, which develops from hormone-producing cells of the anterior pituitary gland – thyrotrophs, manifested by increased secretion of thyroid-stimulating hormone (TSH; thyrotropin), leading to secondary hyperthyroidism. Isolated hypersecretion of TSH is rare; such type of adenomas is usually plurihormonal, i.e. also secretes STH, PRL or other hormones. Thyrotropinoma is one of the most rare pituitary adenomas (about 2-3%).

Treatment of thyrotropinoma

The therapeutic management in patients with corticotropinoma in each case is selected individually. The main method of treatment with thyrotropin is surgical treatment. Also, in some cases, radiation therapy is used. Drug therapy for the thyrotropin-based treatment is used only as an adjunct therapy.